Open AccessLong-Term Variability of Distortion-Product Otoacoustic Emissions in Infants and Children and Its Relation to Pediatric Ototoxicity Monitoring
Author(s) -
Dawn Konrad-Martin,
Keith Knight,
Garnett P. McMillan,
Laura Dreisbach,
Elsa Lubisich Nelson,
Marilyn F. Dille
Publication year - 2017
Publication title -
ear and hearing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.577
H-Index - 109
eISSN - 1538-4667
pISSN - 0196-0202
DOI - 10.1097/aud.0000000000000536
Subject(s) - audiology , ototoxicity , raw score , otoacoustic emission , medicine , context (archaeology) , hearing loss , statistics , raw data , surgery , chemotherapy , mathematics , paleontology , cisplatin , biology
Distortion-product otoacoustic emissions (DPOAEs) provide a rapid, noninvasive measure of outer hair cell damage associated with chemotherapy and are a key component of pediatric ototoxicity monitoring. Serial monitoring of DPOAE levels in reference to baseline measures is one method for detecting ototoxic damage. Interpreting DPOAE findings in this context requires that test-retest differences be considered in relation to normal variability, data which are lacking in children. This study sought to (1) characterize normal test-retest variability in DPOAE level over the long time periods reflective of pediatric chemotherapy regimens for a variety of childhood ages and f2 primary frequencies using common clinical instrumentation and stimulus parameters; (2) develop level-shift reference intervals; and (3) account for any age-related change in DPOAE level or measurement error that may occur as the auditory system undergoes maturational change early in life.