Open AccessGreater Conditioned Pain Modulation Is Associated With Enhanced Morphine Analgesia in Healthy Individuals and Patients With Chronic Low Back Pain
Author(s) -
Stephen Bruehl,
Amanda Stone,
Rajnish K. Gupta,
Asokumar Buvanendran,
Melissa Chont,
John W. Burns
Publication year - 2020
Publication title -
the clinical journal of pain/the clinical journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.109
H-Index - 126
eISSN - 1536-5409
pISSN - 0749-8047
DOI - 10.1097/ajp.0000000000000887
Subject(s) - morphine , visual analogue scale , placebo , medicine , analgesic , chronic pain , anesthesia , opioid , mcgill pain questionnaire , pain catastrophizing , physical therapy , psychology , alternative medicine , receptor , pathology
Conditioned pain modulation (CPM) protocols index magnitude of descending pain inhibition. This study evaluated whether the degree of CPM, controlling for CPM expectancy confounds, was associated with analgesic and subjective responses to morphine and whether chronic pain status or sex moderated these effects.