Open AccessGenome-wide association studies in asthma
Author(s) -
Matthias Wjst,
Muralidharan Sargurupremraj,
Matthias Arnold
Publication year - 2013
Publication title -
current opinion in allergy and clinical immunology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.94
H-Index - 84
eISSN - 1528-4050
pISSN - 1473-6322
DOI - 10.1097/aci.0b013e32835c1674
Subject(s) - linkage disequilibrium , genome wide association study , genetic association , missing heritability problem , genetics , single nucleotide polymorphism , heritability , asthma , computational biology , medicine , biology , allele , haplotype , gene , genotype
Over the past years, several consortia have provided a data deluge from large-scale, genome-wide association studies (GWASs) for numerous asthma and allergy related traits. Dozens of reviews have already summarized the main results, although a coherent picture is still missing, referred to as 'missing' or 'unexplained' heritability.