Open AccessIndoleamine 2,3-dioxygenase expression is associated with chronic rhinosinusitis
Author(s) -
Annika Luukkainen,
Sanna ToppilaSalmi
Publication year - 2013
Publication title -
current opinion in allergy and clinical immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.94
H-Index - 84
eISSN - 1528-4050
pISSN - 1473-6322
DOI - 10.1097/aci.0b013e32835b350e
Subject(s) - medicine , indoleamine 2,3 dioxygenase , nasal polyps , chronic rhinosinusitis , immunology , respiratory tract , autoimmunity , respiratory system , immune system , biology , tryptophan , biochemistry , amino acid
Indoleamine 2,3 dioxygenase (IDO), the key metabolic enzyme implicated in tryptophan catabolism has been studied extensively during the past years in cancer, infections and autoimmunity. This review summarizes the findings of the immunomodulatory effects of IDO. In addition, the possible role of IDO in chronic rhinosinusitis (CRS) is discussed.