Efficacy versus effectiveness trials | Zendy

David Price | Zendy; Elizabeth V. Hillyer | Zendy; Thys van der Molen | Zendy

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Efficacy versus effectiveness trials

Author(s) -

David Price,

Elizabeth V. Hillyer,

Thys van der Molen

Publication year - 2012

Publication title -

current opinion in allergy and clinical immunology

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1528-4050

pISSN - 1473-6322

DOI - 10.1097/aci.0b013e32835ad059

Subject(s) - observational study , medicine , psychological intervention , randomized controlled trial , asthma , inhaler , guideline , clinical trial , intensive care medicine , comparative effectiveness research , medline , alternative medicine , physical therapy , family medicine , nursing , pathology , political science , law

Randomized controlled trials, known as efficacy trials and long considered the gold standard for evidence-based asthma guidelines, are designed to test whether interventions have a benefit for selective patient populations under ideal conditions. The goal of pragmatic trials and observational studies instead is to understand real-life efficacy, known as effectiveness. This review summarizes the strengths and limitations of efficacy and effectiveness trials, results of recent effectiveness trials in asthma and initiatives promoting effectiveness research.

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