Open AccessChildhood asthma in the new omics era: challenges and perspectives
Author(s) -
Korneliusz Golebski,
Michael Kabesch,
Erik Melén,
Uroš Potočnik,
Cornelis M. van Drunen,
Susanne Reinarts,
AnkeHilse Maitlandvan der Zee,
Susanne Vijverberg
Publication year - 2020
Publication title -
current opinion in allergy and clinical immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.94
H-Index - 84
eISSN - 1528-4050
pISSN - 1473-6322
DOI - 10.1097/aci.0000000000000626
Subject(s) - omics , medicine , asthma , precision medicine , endotype , multidisciplinary approach , epigenomics , metabolomics , disease , exposome , data science , genomics , bioinformatics , computer science , pathology , immunology , biology , genome , social science , gene expression , biochemistry , dna methylation , sociology , gene
Childhood asthma is a heterogeneous inflammatory disease comprising different phenotypes and endotypes and, particularly in its severe forms, has a large impact on the quality-of-life of patients and caregivers. The application of advanced omics technologies provides useful insights into underlying asthma endotypes and may provide potential clinical biomarkers to guide treatment and move towards a precision medicine approach.