Open AccessMolecular aspects of allergens in atopic dermatitis
Author(s) -
Raffaela Campana,
Sheron Dzoro,
Irene Mittermann,
Е С Феденко,
O G Elisyutina,
Musa Khaitov,
Alexander Karaulov,
Rudolf Valenta
Publication year - 2017
Publication title -
current opinion in allergy and clinical immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.94
H-Index - 84
eISSN - 1528-4050
pISSN - 1473-6322
DOI - 10.1097/aci.0000000000000378
Subject(s) - atopic dermatitis , medicine , allergen , allergy , immunoglobulin e , immunology , sensitization , desensitization (medicine) , dermatology , antibody , receptor
Molecular allergology uses pure, mainly recombinant and structurally defined allergen molecules and allergen-derived epitopes to study mechanisms of IgE-associated allergy, to diagnose, and even predict the development of allergic manifestations and to treat and prevent IgE-associated allergies. Atopic dermatitis, a chronic inflammatory skin disease is almost always associated with IgE sensitization to allergens. However, also non-IgE-mediated pathomechanisms seem to be operative in atopic dermatitis and it is often difficult to identify the disease-causing allergens. Here we review recent work showing the usefulness of molecular allergology to study mechanisms of atopic dermatitis, for diagnosis and eventually for treatment and prevention of atopic dermatitis.