Open AccessEBV Load in Whole Blood Correlates With LMP2 Gene Expression After Pediatric Heart Transplantation or Allogeneic Hematopoietic Stem Cell Transplantation
Author(s) -
Stephanie Ruf,
Kachina Behnke-Hall,
Bernd Gruhn,
Alfred Reiter,
H Wagner
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000438629.13967.16
Subject(s) - viral load , bzlf1 , transplantation , hematopoietic stem cell transplantation , immunology , lymphoproliferative disorders , population , epstein–barr virus , gene expression , medicine , biology , virus , herpesviridae , gene , lymphoma , viral disease , genetics , environmental health
Epstein-Barr virus (EBV) is associated with posttransplant lymphoproliferative disease (PTLD), and EBV load measurement is an important tool to monitor transplant patients. Although EBV DNA quantification has high sensitivity to identify patients at risk for PTLD, it lacks specificity. We examined whether EBV gene expression in peripheral B cells can increase specificity or correlates with EBV load.