Open AccessLower Variability in 24-Hour Exposure During Once-Daily Compared to Twice-Daily Tacrolimus Formulation in Kidney Transplantation
Author(s) -
Frank Stifft,
L. M. L. Stolk,
Nasrullah Undre,
J. P. van Hooff,
Maarten H. L. Christiaans
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000437561.31212.0e
Subject(s) - tacrolimus , cmin , cyp3a5 , medicine , coefficient of variation , pharmacokinetics , urology , blood concentration , kidney transplantation , transplantation , genotype , kidney transplant , cmax , chemistry , chromatography , biochemistry , gene
Tacrolimus has originally been registered as a twice-daily formulation (Prograf, Tac BID), although a once-daily formulation (Advagraf, Tac QD) is also available. A reduced intrapatient variability of Tac Cmin, a surrogate marker for 24-hour drug exposure (AUC0-24), has been suggested. The variability of AUC0-24 has never been studied prospectively yet. The purpose of this study was to investigate the change in intrapatient variability of Tac AUC0-24 after converting from Tac BID to Tac QD.