Open AccessHigh Urinary Excretion of Kidney Injury Molecule-1 Is an Independent Predictor of Graft Loss in Renal Transplant Recipients
Author(s) -
Mirjan M. van Timmeren,
Vishal S. Vaidya,
Rutger M. van Ree,
Leendert H. Oterdoom,
Aiko P. J. de Vries,
Reinold Gans,
Harry van Goor,
Coen A. Stegeman,
Joseph V. Bonventre,
Stephan J. L. Bakker
Publication year - 2007
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000295982.78039.ef
Subject(s) - urinary system , urology , medicine , kidney , renal injury , excretion , kidney transplant , renal transplant , kidney transplantation , endocrinology
Chronic transplant dysfunction is characterized by renal function decline and proteinuria. Kidney injury molecule (KIM)-1, a transmembrane tubular protein with unknown function, is undetectable in normal kidneys, but markedly induced after injury. Urinary KIM-1 excretion has been quantified as biomarker of renal damage. We prospectively studied whether urinary KIM-1 predicts graft loss, independent of renal function and proteinuria.