Open AccessAcute Lung Transplant Rejection Is Associated With Localized Increase in T-Cell IFNγ and TNFα Proinflammatory Cytokines in the Airways
Author(s) -
Greg Hodge,
Sandra Hodge,
D.C. Chambers,
Paul N. Reynolds,
Mark Holmes
Publication year - 2007
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000290679.94163.e1
Subject(s) - proinflammatory cytokine , immunology , cytokine , medicine , bronchoalveolar lavage , cd8 , tumor necrosis factor alpha , t cell , lung transplantation , immunosuppression , transplantation , immune system , lung , inflammation
Allograft rejection remains a major cause of morbidity and mortality after lung transplantation and is associated with increased gene expression for proinflammatory cytokines. T cells are a major cell type involved in graft rejection. There have been no previous studies of cytokine production by T cells from blood, bronchoalveolar lavage (BAL), and intraepithelial T cells from bronchial brushings (BB) during rejection episodes; we hypothesized that T-cell proinflammatory cytokines would be increased in the airways during rejection episodes despite standard immunosuppression regimens.