Toll-Like Receptor 4 Mediates the Early Inflammatory Response After Cold Ischemia/Reperfusion | Zendy

David J. Kaczorowski | Zendy; Atsunori Nakao | Zendy; Kevin P. Mollen | Zendy; Raghuveer Vallabhaneni | Zendy; Ryujiro Sugimoto | Zendy; Junichi Kohmoto | Zendy; Kimimasa Tobita | Zendy; Brian S. Zuckerbraun | Zendy; Kenneth R. McCurry | Zendy; Noriko Murase | Zendy; Timothy R. Billiar | Zendy

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Toll-Like Receptor 4 Mediates the Early Inflammatory Response After Cold Ischemia/Reperfusion

Author(s) -

David J. Kaczorowski,

Atsunori Nakao,

Kevin P. Mollen,

Raghuveer Vallabhaneni,

Ryujiro Sugimoto,

Junichi Kohmoto,

Kimimasa Tobita,

Brian S. Zuckerbraun,

Kenneth R. McCurry,

Noriko Murase,

Timothy R. Billiar

Publication year - 2007

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/01.tp.0000287597.87571.17

Subject(s) - tumor necrosis factor alpha , wild type , inflammation , tlr4 , reperfusion injury , biology , receptor , immunology , interleukin , hmgb1 , microbiology and biotechnology , cytokine , mutant , endocrinology , medicine , ischemia , biochemistry , gene

Ischemia/reperfusion (I/R) injury leads to graft dysfunction and may contribute to alloimmune responses posttransplantation. The molecular mechanisms of cold I/R injury are only partially characterized but may involve toll-like receptor (TLR)-4 activation by endogenous ligands. We tested the hypothesis that TLR4 mediates the early inflammatory response in the setting of cold I/R in a murine cardiac transplant model.

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