Open AccessAlloimmune Lung Injury Induced by Local Innate Immune Activation Through Inhaled Lipopolysaccharide
Author(s) -
Stavros Garantziotis,
Scott M. Palmer,
Laurie D. Snyder,
Tonya M. Ganous,
Benny J. Chen,
Tie Wang,
Donald N. Cook,
David A. Schwartz
Publication year - 2007
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000286040.85007.89
Subject(s) - alloimmunity , immunology , tlr4 , innate immune system , lung , medicine , inflammation , immune system , lipopolysaccharide , toll like receptor
Alloimmune lung injury, characterized by perivascular lymphocytic inflammation, lymphocytic bronchiolitis (LB), and obliterative bronchiolitis (OB), causes substantial morbidity and mortality after lung transplantation and bone marrow transplantation (BMT), but little is known regarding its pathogenesis. We have developed and pursued the hypothesis that local activation of pulmonary innate immunity through toll-like receptor (TLR)-4 is critical to the development of posttransplant alloimmune lung injury.