Open AccessEvidence for Genetic Susceptibility Towards Development of Posttransplant Lymphoproliferative Disorder in Solid Organ Recipients
Author(s) -
Nina Babel,
Athanasios Vergopoulos,
Ralf Ulrich Trappe,
Stephan Oertel,
Markus Hammer,
Stoyan Karaivanov,
Natália Schneider,
Hanno Riess,
Matthias Papp-Váry,
R. Neuhaus,
Lukasz P. Gondek,
HansDieter Volk,
Petra Reinke
Publication year - 2007
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000269617.60751.c4
Subject(s) - odds ratio , genotype , single nucleotide polymorphism , organ transplantation , immunology , medicine , lymphoproliferative disorders , gastroenterology , transplantation , biology , lymphoma , gene , genetics
Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication after organ transplantation. The identification of risk factors for PTLD development is important for disease management. It has been shown that cytokine gene polymorphisms are associated with lymphoma and Epstein-Barr virus (EBV)-associated diseases in nonimmunosuppressed patients. In the present case-control study, we analyzed the impact of -1082 interleukin (IL)-10, -308 tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 (codon 10, 25), and +874 interferon (IFN)-gamma gene single-nucleotide polymorphisms on the late onset EBV-associated PTLD.