Open AccessTransplant Tolerance Associated With a Th1 Response and Not Broken by IL-4, IL-5, and TGF-β Blockade or Th1 Cytokine Administration
Author(s) -
Karren M. Plain,
Rochelle Boyd,
Nirupama D. Verma,
Catherine M. Robinson,
Giang Tran,
S. Hodgkinson,
Bruce M. Hall
Publication year - 2007
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000256326.11647.2e
Subject(s) - cytokine , immunology , monoclonal antibody , il 2 receptor , immune tolerance , t cell , mixed lymphocyte reaction , antigen , medicine , biology , antibody , immune system
Specific transplant tolerance is mediated by CD4 T cells that die unless supported by T-cell derived cytokines and donor antigen. This study examined the role of Th1 and Th2 cytokines in the maintenance of tolerance.