Loss of the ??-Isoform of Calcineurin Is Sufficient to Induce Nephrotoxicity and Altered Expression of Transforming Growth Factor-?? | Zendy

Jennifer L. Gooch | Zendy; Brian R. Roberts | Zendy; Scott L. Cobbs | Zendy; James A. Tumlin | Zendy

Open Access

Loss of the ??-Isoform of Calcineurin Is Sufficient to Induce Nephrotoxicity and Altered Expression of Transforming Growth Factor-??

Author(s) -

Jennifer L. Gooch,

Brian R. Roberts,

Scott L. Cobbs,

James A. Tumlin

Publication year - 2007

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/01.tp.0000251423.78124.51

Subject(s) - calcineurin , fibronectin , nephrotoxicity , fibrosis , downregulation and upregulation , transforming growth factor , transforming growth factor beta , extracellular matrix , biology , in vivo , gene isoform , endocrinology , microbiology and biotechnology , medicine , chemistry , kidney , transplantation , biochemistry , gene

Use of calcineurin inhibitors is frequently limited by fibrosis, closely linked with increased transforming growth factor (TGF)-beta. However, mechanisms of extracellular matrix expansion and TGFbeta regulation following calcineurin inhibition are unknown. Mice lacking specific calcineurin catalytic subunit isoforms may offer important insight into this pathway.

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