Open AccessPancreas Transplantation Under Alemtuzumab (Campath-1H) and Tacrolimus: Correlation Between Low T-Cell Responses and Infection
Author(s) -
Ngoc Thai,
Deanna Blisard,
Kusum Tom,
Amit Basu,
Cynthia Smetanka,
Henkie P. Tan,
Carol Bentlejewski,
Janice Glidewell,
Judy Britz,
Richard Kowalski,
Ron Shapiro,
John J. Fung,
Amadeo Marcos,
Adriana Zeevi
Publication year - 2006
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000250655.14026.5c
Subject(s) - immunosuppression , alemtuzumab , medicine , tacrolimus , pancreas transplantation , transplantation , immunology , immune system , gastroenterology , t cell , kidney transplantation
Alemtuzumab induction and tacrolimus-based immunosuppression has been effective in pancreas transplantation. Despite the encouraging results of this minimalistic approach to immunosuppression, infection still remains a significant cause of morbidity. The Cylex ImmuKnow [corrected] assay was used in this study to compare pancreas recipient clinical states (stable, rejection, infection) with T cell responses.