Suppression of (5R)-5-hydroxytriptolide (LLDT-8) on Allograft Rejection in Full MHC-Mismatched Mouse Cardiac Transplantation | Zendy

Wei Tang | Zendy; Ru Zhou | Zendy; Yang Yang | Zendy; Yuanchao Li | Zendy; Yifu Yang | Zendy; Jianping Zuo | Zendy

Open Access

Suppression of (5R)-5-hydroxytriptolide (LLDT-8) on Allograft Rejection in Full MHC-Mismatched Mouse Cardiac Transplantation

Author(s) -

Wei Tang,

Ru Zhou,

Yang Yang,

Yuanchao Li,

Yifu Yang,

Jianping Zuo

Publication year - 2006

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/01.tp.0000203299.39843.d2

Subject(s) - transplantation , immunology , cd8 , chemokine , t cell , medicine , ex vivo , major histocompatibility complex , in vivo , immune system , biology , microbiology and biotechnology

(5R)-5-hydroxytriptolide (LLDT-8) is a new compound derived from triptolide, which is the major immunosuppressive fraction of Tripterygium wilfordii Hook. F (TWHF). Studies in vitro and in vivo have demonstrated that LLDT-8 had potent immunosuppressive activities. Here we tested LLDT-8 in major histocompatibility complex (MHC)-mismatched cardiac transplantation and investigated the mechanisms underlying the prevention of transplant rejection.

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