Open AccessSuppression of (5R)-5-hydroxytriptolide (LLDT-8) on Allograft Rejection in Full MHC-Mismatched Mouse Cardiac Transplantation
Author(s) -
Wei Tang,
Ru Zhou,
Yang Yang,
Yuanchao Li,
Yang Yang,
JianPing Zuo
Publication year - 2006
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000203299.39843.d2
Subject(s) - transplantation , immunology , cd8 , chemokine , t cell , medicine , ex vivo , major histocompatibility complex , in vivo , immune system , biology , microbiology and biotechnology
(5R)-5-hydroxytriptolide (LLDT-8) is a new compound derived from triptolide, which is the major immunosuppressive fraction of Tripterygium wilfordii Hook. F (TWHF). Studies in vitro and in vivo have demonstrated that LLDT-8 had potent immunosuppressive activities. Here we tested LLDT-8 in major histocompatibility complex (MHC)-mismatched cardiac transplantation and investigated the mechanisms underlying the prevention of transplant rejection.