Open AccessSimian Parvovirus Infection in Cynomolgus Monkey Heart Transplant Recipients Causes Death Related to Severe Anemia
Author(s) -
Carsten Schröder,
Steffen Pfeiffer,
Guosheng Wu,
Agnes M. Azimzadeh,
Amanda L. Aber,
Richard N. Pierson,
M. Gerard O’Sullivan
Publication year - 2006
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000203170.77195.e4
Subject(s) - viremia , parvovirus , asymptomatic , immunology , medicine , anemia , transplantation , immunosuppression , heart transplantation , virus , virology , pathology
Simian parvovirus (SPV) was first isolated from cynomolgus monkeys. Like human parvovirus B19, this virus has a predilection for erythroid cells. During acute SPV infection, clinical signs are usually mild or inapparent, but severe anemia may occur in immunocompromised animals. We report several cases of symptomatic SPV infection in cynomolgus monkeys following heart transplantation.