Open AccessRapamycin Does Not Induce Anergy but Inhibits Expansion and Differentiation of Alloreactive Human T Cells
Author(s) -
Natalia Nikolaeva,
Fréderike J. Bemelman,
S. L. Yong,
R. A. W. Van Lier,
Ineke J. M. ten Berge
Publication year - 2006
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000194860.21533.b9
Subject(s) - cytotoxic t cell , il 2 receptor , microbiology and biotechnology , granzyme b , perforin , biology , t cell , cd8 , interleukin 21 , chemistry , immunology , immune system , in vitro , biochemistry
Studies in mice have shown that rapamycin inhibits cell cycle progression and promotes the development of clonal anergy. We here addressed the question if rapamycin can induce anergy of human T cells and studied the effects of rapamycin on activation, proliferation and expression of cytotoxic effector molecules of alloresponsive T cells in mixed lymphocyte cultures.