Open AccessNonmyeloablative Conditioning Does Not Prevent Telomere Shortening after Allogeneic Stem Cell Transplantation
Author(s) -
Meir Lahav,
Orit Uziel,
Meir Kestenbaum,
Abigail Fraser,
Hava Shapiro,
Judith Radnay,
Martine SzyperKravitz,
Shimoni Avihai,
Izhar Hardan,
Noga ShemTov,
Ar Nagler
Publication year - 2005
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000173649.99261.df
Subject(s) - telomere , transplantation , stem cell , hematopoietic stem cell transplantation , haematopoiesis , senescence , immunology , biology , medicine , oncology , genetics , dna
Stem cell transplantation (SCT) may be associated with premature aging of the hematopoietic stem cells. Telomere length reflects the proliferative history of a cell. In most studies published so far on telomere dynamics after myeloablative allogeneic SCT, recipients had shorter telomeres than their respective donors, thus reflecting "accelerated aging" of hematopoietic cells. We evaluated telomere dynamics in patients who underwent transplantation with nonmyeloablative protocols, assuming that the decreased intensity of chemotherapy might prevent telomere attrition.