Open AccessA Novel Small-Molecule Compound Targeting CCR5 and CXCR3 Prevents Acute and Chronic Allograft Rejection
Author(s) -
Satoru Akashi,
Masayuki Sho,
Hisanori Kashizuka,
Kaoru Hamada,
Naoya Ikeda,
Yukiyasu Kuzumoto,
Yoshikazu Tsurui,
Takeo Nomi,
Takashi Mizuno,
Hiromichi Kanehiro,
Michiyoshi Hisanaga,
Saiho Ko,
Yoshiyuki Nakajima
Publication year - 2005
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000166338.99933.e1
Subject(s) - cxcr3 , immunology , chemokine , chemokine receptor , ccr2 , transplantation , c c chemokine receptor type 7 , medicine , major histocompatibility complex , biology , immune system
Chemokines and chemokine receptors are critical in leukocyte recruitment, activation, and differentiation. Among them, CC chemokine receptor 5 (CCR5) and CXC chemokine receptor 3 (CXCR3) have been reported to play important roles in alloimmune responses and may be potential targets for posttransplant immunosuppression.