Open AccessExpression of Biologically Active Human TRAIL in Transgenic Pigs
Author(s) -
Regina Klose,
Elisabeth Kemter,
Tanja Bedke,
Iris Bittmann,
Barbara Keler,
Robert G. Endres,
Klaus Pfeffer,
Reinhard Schwinzer,
Eckhard Wolf
Publication year - 2005
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000164817.59006.c2
Subject(s) - xenotransplantation , transgene , biology , jurkat cells , immune system , genetically modified mouse , microbiology and biotechnology , apoptosis , immunology , transplantation , t cell , medicine , gene , biochemistry
Xenotransplantation of porcine organs into human recipients is a potential option for overcoming the dramatic shortage of suitable donor organs. To date, transgenic modification of pig organs has achieved partial or temporal reduction of xenograft rejection by inhibition of hyperacute rejection. Expression of human tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) in transgenic pigs might be a strategy for controlling posthyperacute rejection mechanisms mediated by cellular components of the immune system. The objective of this study was generation of a transgenic pig model to evaluate the potential of this strategy for xenotransplantation.