Open AccessSuppression of the Cell-Mediated Immune Response by a Fas-Immunoglobulin Fusion Protein
Author(s) -
Yongping Shen,
Brian J. Young,
Mark L. Lipman
Publication year - 2006
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000164289.18470.28
Subject(s) - fas ligand , immune system , microbiology and biotechnology , fusion protein , t cell , biology , antibody , chemistry , apoptosis , immunology , programmed cell death , biochemistry , gene , recombinant dna
Immunosuppressive agents must not only be effective in impairing the host's allo-immune response, but should also be selective in targeting only those elements of the immune system activated by the allograft. The fact that allo-activated T cells express surface protein molecules that are not typically present on resting T cells can be exploited to specifically target this population. Fas ligand is one such molecule whose cell surface expression on T cells is dramatically up-regulated upon activation.