Open AccessDifferences in Suppressor of Cytokine Signaling-1 (SOCS-1) Expressing Islet Allograft Destruction in Normal BALB/c and Spontaneously-Diabetic NOD Recipient Mice
Author(s) -
Michelle Solomon,
Malin FlodströmTullberg,
Nora Sarvetnick
Publication year - 2005
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000162979.66954.53
Subject(s) - islet , nod mice , cytokine , nod , transplantation , renal capsule , endocrinology , beta cell , downregulation and upregulation , medicine , immunology , biology , insulin , diabetes mellitus , biochemistry , gene
The ability to block interferon signaling represents an important strategy in designing therapies to prevent beta-cell destruction during islet allograft rejection.