Open AccessRole of the ICOS-B7h Costimulatory Pathway in the Pathophysiology of Chronic Allograft Rejection
Author(s) -
Hisanori Kashizuka,
Masayuki Sho,
Takeo Nomi,
Naoya Ikeda,
Yukiyasu Kuzumoto,
Satoru Akashi,
Yoshikazu Tsurui,
Takashi Mizuno,
Hiromichi Kanehiro,
Hideo Yagita,
Yoshiyuki Nakajima,
Mohamed H. Sayegh
Publication year - 2005
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000161665.35243.21
Subject(s) - blockade , immunology , chemokine , medicine , transplantation , fibrosis , monoclonal antibody , infiltration (hvac) , effector , immune system , antibody , receptor , pathology , physics , thermodynamics
Inducible costimulator (ICOS) is the third member of the CD28 superfamily and has a unique role in T cell activation and function. Recent studies indicated that the ICOS-B7h pathway plays an important role in alloimmune responses. We further investigated the role of the ICOS pathway in the pathologic process of chronic rejection in vivo.