Open AccessCompetitive Equality of Donor Cells Expressing a Disparate MHC Antigen following Stem Cell-Enriched Bone Marrow Transplantation
Author(s) -
Jialin Zhang,
Jiabing Cai,
John D. Jackson,
Shan Walls,
Charles Kuszynski,
Ira J. Fox
Publication year - 2005
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000159871.01132.5d
Subject(s) - bone marrow , biology , immunology , haematopoiesis , population , stem cell , transplantation , major histocompatibility complex , antigen , microbiology and biotechnology , medicine , environmental health
Bone marrow cells expressing foreign MHC antigens survive poorly after transplantation. Stable mixed hematopoietic chimerism requires reconstitution with a relatively large number of foreign bone marrow cells and intensive depletion of host cells. In addition, when foreign MHC-transduced autologous bone marrow cells are transplanted, prolonged hematopoietic transgene expression requires extensive host conditioning. The competitive disadvantage associated with engraftment of donor cells expressing foreign MHC antigens is thought to result from a defect in engraftment secondary to donor-host incompatibility or immunologic resistance by the host.