Open AccessB Cell Allogeneic Responses after Hematopoietic Cell Transplantation: Is It Time to Address this Issue?
Author(s) -
Sylvain Perruche,
F. Kleinclauss,
Pierre Tiberghien,
Philippe Saas
Publication year - 2005
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000153299.99024.0f
Subject(s) - transplantation , hematopoietic cell , immunology , haematopoiesis , graft versus host disease , transplantation chimera , hematopoietic stem cell transplantation , cell , immune system , disease , medicine , biology , stem cell , microbiology and biotechnology , genetics
To date, B cell responses have retained less attention than T, natural killer or dendritic cell responses in the alloreactive conflict after allogeneic hematopoietic cell transplantation (HCT). Here, we discuss recent clinical and experimental data supporting a role of allogeneic B cell responses in graft-host interactions after HCT. We report results in a murine model of reduced intensity conditioning transplantation (RICT) showing that host B cells can be involved in chronic graft-versus-host disease occurrence. We also describe the control of antidonor alloresponses by intravenous simultaneous infusion of apoptotic cells with allogeneic hematopoietic grafts.