Open AccessTolerizing Effects of Co-stimulation Blockade Rest on Functional Dominance of CD4+CD25+ Regulatory T Cells
Author(s) -
Jeroen J. A. Coenen,
Hans J. P. M. Koenen,
Esther van Rijssen,
Luuk B. Hilbrands,
Irma Joosten
Publication year - 2005
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000147460.93587.87
Subject(s) - regulatory t cell , effector , il 2 receptor , biology , microbiology and biotechnology , cd86 , t cell , population , mixed lymphocyte reaction , stimulation , immune tolerance , blockade , immunology , immune system , medicine , receptor , neuroscience , genetics , environmental health
Clinical tolerance is the net result of regulatory and effector functions. In this article, the authors show that tolerance induction by co-stimulation blockade preferentially works through CD4CD25 regulatory T-cell-mediated suppression that is effectively achieved by selective reduction of the effector T-cell load. Anti-CD86 and anti-CD40L monoclonal antibody treatment during in vitro mixed lymphocyte reaction (MLR) typically results in the induction of a suppressive polyclonal T-cell population. This induced suppressive capacity was found to be dependent on the presence of CD4CD25 T cells at the start of MLR.