Open AccessEffect of Mediators of Innate Immunity and Inflammation on CD8+ Veto Cells
Author(s) -
James C. Zimring,
Traci E. Chadwick,
Christopher D. Hillyer,
John D. Roback
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000144322.48212.14
Subject(s) - veto , innate immune system , immunology , biology , cd8 , tumor necrosis factor alpha , immunity , immune system , interferon , inflammation , lipopolysaccharide , microbiology and biotechnology , political science , politics , law
Methods of allotolerance induction that are successful in mice often fail in primates. Activators of innate immunity derived from microbial pathogens, which are present in primate populations but not in pathogen-free mouse colonies, have been shown to overcome tolerance induction by co-stimulatory blockade or regulatory T cells. Unlike other strategies, veto cells promote long-term allograft survival in primates. Accordingly, the authors hypothesized that veto cells are resistant to the effects of innate immune activation.