Open AccessInduction of Xenogeneic Neonatal Tolerance to Transgenic Human Leukocyte Antigen Class I Grafts
Author(s) -
Steven H. Borenstein,
K. Tao,
Ningjie Hu,
Lori J. West,
John W. Chamberlain
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000136965.22023.60
Subject(s) - major histocompatibility complex , xenotransplantation , immunology , human leukocyte antigen , immune tolerance , immune system , biology , transgene , antigen , histocompatibility , humanized mouse , genetically modified mouse , miniature swine , mhc class i , transplantation , immunologic tolerance , genetics , medicine , gene , surgery
The immune response against xenografts is vigorous and poorly controlled with conventional immunosuppressants. Therefore, success in xenotransplantation will depend on developing additional approaches such as induction of immunologic unresponsiveness or tolerance. Although classic protocols of neonatal tolerance induction in mice are very tolerogenic in many allogeneic models, they have generally failed in xenogeneic models. The purpose of these studies was to determine whether failure results from an intrinsic property of xenogenic major histocompatibility complex (MHC) molecules themselves or, instead, is caused by some limitation in species-specific molecular interactions distinct from the polymorphic domains of xenogenic MHC molecules.