Open AccessHemorrhagic Cystitis in Children Undergoing Bone Marrow Transplantation: A Putative Role for Simian Virus 40
Author(s) -
Manola Comar,
Pierlanfranco D’Agaro,
M Andolina,
Natalia Maximova,
Fernanda Martini,
Mauro Tog,
Cesare Campello
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000136257.02830.29
Subject(s) - hemorrhagic cystitis , bk virus , polymerase chain reaction , virology , peripheral blood mononuclear cell , virus , jc virus , biology , betaherpesvirinae , cytomegalovirus , amplicon , herpesviridae , transplantation , viral disease , microbiology and biotechnology , medicine , gene , hematopoietic stem cell transplantation , kidney transplantation , biochemistry , progressive multifocal leukoencephalopathy , in vitro
Late-onset hemorrhagic cystitis (HC) is a well-known severe complication of bone marrow transplantation (BMT), both in adults and in children. Protracted postengraftment HC is associated with graft-versus-host disease and viral infections, mainly caused by BK virus (BKV) or adenovirus (AV). This study investigated whether simian virus 40 (SV40) DNA sequences can be detected in specimens from pediatric patients affected by severe postengraftment HC.