Open AccessCompared with Cyclosporine, ISATX247 Significantly Prolongs Renal-Allograft Survival in a Nonhuman Primate Model
Author(s) -
Clare R. Gregory,
Andrew E. Kyles,
Lynda Bernsteen,
Gerhardt S. Wagner,
Alice F. Tarantal,
Kari L Christe,
Lori Brignolo,
Abigail Spinner,
Stephen M. Griffey,
Ricardo Paniagua,
Richard W Hubble,
Dominic C. Borie,
Randall E. Morris
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000131950.75697.71
Subject(s) - calcineurin , transplantation , nonhuman primate , creatinine , medicine , urology , potency , ciclosporin , trough level , whole blood , pharmacology , kidney , tacrolimus , chemistry , biology , in vitro , biochemistry , evolutionary biology
ISATX247 is a novel calcineurin inhibitor that has shown more potency than cyclosporine in vitro. This is the first study to compare the survival times of renal allografts in nonhuman primates treated with either ISATX247 or cyclosporine.