Open AccessROLE OF XANTHINE OXIDOREDUCTASE IN EXPERIMENTAL ACUTE RENAL-ALLOGRAFT REJECTION
Author(s) -
Kai Sun,
Éva Kiss,
Jens Bedke,
Tomislav Stojanović,
Yanhua Li,
Wilfried Gwinner,
Hermann Josef Gröne
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000131169.29553.b1
Subject(s) - xanthine oxidase , reactive oxygen species , allopurinol , kidney , medicine , transplantation , antioxidant , mycophenolate , pharmacology , immunology , enzyme , chemistry , biochemistry
Increased oxygen radical production may not only contribute to posttransplant ischemia-reperfusion injury but also to acute rejection of renal allografts. Xanthine oxidoreductase (XOR) may constitute a relevant reactive oxygen species (ROS) source. The study was conducted (1). to determine ROS production as well as oxidant and antioxidant enzyme activities in renal grafts and (2). to modulate acute rejection by tungsten administration, a specific inhibitor of XOR.