Open AccessCYCLOSPORINE A MEDIATES FIBROPROLIFERATION THROUGH EPITHELIAL CELLS
Author(s) -
Katrin Hostettler,
Michael Roth,
Janette K. Burgess,
Patricia A. Johnson,
Allan R. Glanville,
Michael Tamm,
Judith L. Black,
Pieter Borger
Publication year - 2004
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000131149.78168.dd
Subject(s) - fibroblast , epithelium , transplantation , cell growth , fibroblast growth factor , cancer research , biology , andrology , immunology , microbiology and biotechnology , endocrinology , medicine , pathology , cell culture , receptor , biochemistry , genetics
Obliterative bronchiolitis (OB) is the major cause of morbidity and mortality after lung transplantation. The potential role of immunosuppressive drugs in the development of OB is uncertain, but there are limited data indicating that cyclosporine A (CsA) may have a direct fibrogenic effect on various human cell types. Epithelium-fibroblast interactions have been suggested to play a crucial role in the course of fibroproliferation, which is a major feature of OB.