Open AccessMYCOPHENOLATE MOFETIL PREVENTS TRANSPLANT ARTERIOSCLEROSIS BY DIRECT INHIBITION OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATION1
Author(s) -
Hisashi Shimizu,
Masafumi Takahashi,
Shinichi Takeda,
Seiichiro Inoue,
Jun Fujishiro,
Yoji Hakamata,
Takashi Kaneko,
Takashi Murakami,
Koichi Takeuchi,
Izumi Takeyoshi,
Yasuo Morishita,
Eiji Kobayashi
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000127592.13707.b6
Subject(s) - neointima , adventitia , transplantation , osteopontin , medicine , arteriosclerosis , vascular smooth muscle , platelet derived growth factor receptor , mycophenolate , pathology , platelet derived growth factor , intimal hyperplasia , chemistry , growth factor , immunology , endocrinology , receptor , restenosis , stent , smooth muscle
BACKGROUND.: Transplant arteriosclerosis is one of the main features of chronic graft failure in organ transplantation. In this article, the authors investigate mechanisms of mycophenolate mofetil (MMF) on prevention of transplant arteriosclerosis in a rat aortic allograft model.