Open AccessIN VIVO-MOBILIZED KIDNEY DENDRITIC CELLS ARE FUNCTIONALLY IMMATURE, SUBVERT ALLOREACTIVE T-CELL RESPONSES, AND PROLONG ORGAN ALLOGRAFT SURVIVAL1
Author(s) -
P. Toby Coates,
F. Jason Duncan,
Bridget L. Colvin,
Zhiliang Wang,
Alan F. Zahorchak,
William J. Shufesky,
Adrián E. Morelli,
Angus W. Thomson
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000122183.60680.c9
Subject(s) - biology , dendritic cell , transplantation , immunology , ex vivo , t cell , antigen , microbiology and biotechnology , cytotoxic t cell , in vivo , immune system , medicine , in vitro , biochemistry
Migratory antigen-presenting cells resident in kidneys may have tolerogenic potential. Difficulties inherent in their isolation have limited their characterization. The authors examined the phenotype and function of murine kidney dendritic cells (DC) mobilized in vivo by systemic administration of fms-like tyrosine 3 kinase ligand (Flt3L).