Open AccessTolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine1
Author(s) -
Shehan Hettiaratchy,
Elizabeth Melendy,
Mark A. Randolph,
Rebecca C. Coburn,
David M. Neville,
David H. Sachs,
Christene A. Huang,
W. P.Andrew Lee
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000113806.52063.42
Subject(s) - bone marrow , immunology , peripheral blood mononuclear cell , medicine , miniature swine , microchimerism , histocompatibility , immune tolerance , haematopoiesis , major histocompatibility complex , transplantation , t cell , lymphocyte , cytokine , graft versus host disease , immune system , stem cell , biology , antigen , in vitro , human leukocyte antigen , surgery , pregnancy , biochemistry , fetus , genetics
Tolerance to composite tissue allografts might allow the widespread clinical use of reconstructive allotransplantation if protocols to achieve this could be rendered sufficiently nontoxic. The authors investigated whether tolerance could be generated in miniature swine to composite tissue allografts across a major histocompatibility (MHC) barrier. A clinically relevant tolerance protocol involving hematopoietic cell transplantation without the need for irradiation or myelosuppressive drugs was tested.