Open AccessRegulatory T cells: potential in organ transplantation.1
Author(s) -
Kathryn J. Wood,
Senlin Luo,
Ahmed Akl
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000106477.70852.29
Subject(s) - transplantation , il 2 receptor , immunology , immune system , organ transplantation , mechanism (biology) , biology , antigen , microbiology and biotechnology , t cell , medicine , philosophy , epistemology
Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune responsiveness after organ or cell transplantation. In many settings, immunoregulatory activity is enriched in CD4+ T cells that express high levels of CD25, and common mechanisms appear to be responsible for the activity of regulatory T cells in both transplantation and the control of reactivity to self-antigens.