Open AccessEffects of adding P38 mitogen-activated protein-kinase inhibitor to celsior solution in canine heart transplantation from non???heart-beating donors
Author(s) -
Norimasa Koike,
Izumi Takeyoshi,
Shinya Ohki,
Masahiko Tokumine,
Koshi Matsumoto,
Yasuo Morishita
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000101039.12835.a4
Subject(s) - medicine , heart transplantation , transplantation , cardiopulmonary bypass , anesthesia , cardiology , reperfusion injury , mapk/erk pathway , ischemia , surgery , kinase , biology , biochemistry
The activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in ischemia-reperfusion injury. This study evaluated the effects of p38 MAPK inhibition using FR167653, a novel p38 MAPK inhibitor, as an additive to Celsior solution in canine heart transplantation from non-heart-beating donors (NHBDs).