Open AccessRestoration of functional motor units in a rat model of sphincter injury by muscle precursor cell autografts1
Author(s) -
R. Yiou,
James J. Yoo,
Anthony Atala
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000090396.71097.c2
Subject(s) - sphincter , urethral sphincter , denervation , medicine , urology , myogenesis , fibrosis , neuromuscular junction , regeneration (biology) , atrophy , myocyte , surgery , anatomy , urinary incontinence , biology , neuroscience , microbiology and biotechnology
Urinary incontinence is a debilitating condition that affects primarily elderly individuals. One major mechanism results from chronic denervation of the striated urethral sphincter with associated fibrosis. The authors investigated the fate of muscle precursor cells (MPC) injected into a model of striated urethral sphincter injury that reproduces the histopathologic changes of sphincter insufficiency.