Open AccessDifferential effect of cyclosporine A and SDZ RAD on neointima formation of carotid allografts in apolipoprotein E-deficient mice
Author(s) -
Yuji Matsumoto,
Akiko Hof,
Yves Baumlin,
Robert P. Hof
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000090393.75600.32
Subject(s) - neointima , allotransplantation , medicine , apolipoprotein e , transplantation , placebo , pharmacology , apolipoprotein b , endocrinology , cholesterol , urology , pathology , restenosis , stent , disease , alternative medicine
Apolipoprotein E-deficient (apoE-/-) mice spontaneously develop hypercholesterolemia and atherosclerotic lesions. This may be an appropriate background for the development of graft vessel disease. The authors therefore investigated the effects of cyclosporine A (CsA) and SDZ RAD (RAD, everolimus, Certican) on neointima formation of carotid allografts in apoE-/- mice. To ascertain that equipotent immunosuppressive doses were used, the authors also investigated their effects on cardiac allografts using the same wild-type strain combination.