Heat shock protein 70: correlation of expression with degree of graft-versus-host response and clinical graft-versus-host disease1 | Zendy

M. Jarvis | Zendy; Maria A. V. Marzolini | Zendy; X. N. Wang | Zendy; G Jackson | Zendy; Lisbet Sviland | Zendy; Anne M. Dickinson | Zendy

Open Access

Heat shock protein 70: correlation of expression with degree of graft-versus-host response and clinical graft-versus-host disease1

Author(s) -

M. Jarvis,

Maria A. V. Marzolini,

X. N. Wang,

G Jackson,

Lisbet Sviland,

Anne M. Dickinson

Publication year - 2003

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/01.tp.0000083556.73555.78

Subject(s) - pathogenesis , hsp70 , heat shock protein , immunohistochemistry , graft versus host disease , immunology , acquired immune system , transplantation , immunity , medicine , biology , antigen , immune system , pathology , disease , gene , biochemistry

The heat shock proteins are increasingly becoming associated with immunopathologic phenomena, being induced in response to inflammation. They are highly immunogenic and are postulated as playing a role in both innate and adaptive immunity. Their proposed role in peptide binding and antigen presentation could suggest a potential role in the alloreactive process that leads to graft-versus-host disease (GVHD) after bone marrow transplantation.

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