Open AccessHeat shock protein 70: correlation of expression with degree of graft-versus-host response and clinical graft-versus-host disease1
Author(s) -
Mark Jarvis,
Maria A V Marzolini,
X. N. Wang,
GH Jackson,
Lisbet Sviland,
Anne M. Dickinson
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000083556.73555.78
Subject(s) - pathogenesis , hsp70 , heat shock protein , immunohistochemistry , graft versus host disease , immunology , acquired immune system , transplantation , immunity , medicine , biology , antigen , immune system , pathology , disease , gene , biochemistry
The heat shock proteins are increasingly becoming associated with immunopathologic phenomena, being induced in response to inflammation. They are highly immunogenic and are postulated as playing a role in both innate and adaptive immunity. Their proposed role in peptide binding and antigen presentation could suggest a potential role in the alloreactive process that leads to graft-versus-host disease (GVHD) after bone marrow transplantation.