Open AccessMembrane pore size impacts performance of a xenogeneic bioartificial liver1
Author(s) -
T. Matsushita,
Bruce Amiot,
Joseph A. Hardin,
Jeffrey L. Platt,
Scott L. Nyberg
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000080067.79190.3c
Subject(s) - bioartificial liver device , spheroid , antibody titer , membrane , transplantation , viability assay , immune system , medicine , antibody , andrology , membrane permeability , titer , permeability (electromagnetism) , cell , hepatocyte , immunology , chemistry , pathology , in vitro , biochemistry
We have developed a novel bioartificial liver (BAL) composed of porcine hepatocyte spheroids in a reservoir design. A semipermeable membrane is used to protect the spheroids from immune-mediated damage. This study was designed to assess the influence of membrane pore size on performance of the spheroid reservoir BAL.