Open AccessRAPID ESTABLISHMENT OF LONG-TERM CULTURE-INITIATING CELLS OF DONOR ORIGIN AFTER NONMYELOABLATIVE ALLOGENEIC HEMATOPOIETIC STEM-CELL TRANSPLANTATION, AND SIGNIFICANT PROGNOSTIC IMPACT OF DONOR T-CELL CHIMERISM ON STABLE ENGRAFTMENT AND PROGRESSION-FREE SURVIVAL
Author(s) -
Felix Keil,
Erika Prinz,
Karin Moser,
Christine Mannhalter,
Peter Kalhs,
Nina Worel,
Werner Rabitsch,
Axel Schulenburg,
Margit Mitterbauer,
Hildegard Greinix
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000071862.42835.76
Subject(s) - stem cell , fludarabine , haematopoiesis , medicine , myeloid , cd34 , transplantation , immunology , transplantation chimera , hematopoietic stem cell transplantation , progenitor cell , total body irradiation , cancer research , biology , chemotherapy , cyclophosphamide , hematopoietic cell , genetics
Nonmyeloablative allogeneic hematopoietic stem-cell transplantation (NST) allows establishment of donor hematopoiesis without eradication of recipient stem cells by chemoradiotherapy. Quantification of donor chimerism may predict graft failure and relapse.