Open AccessBLOCKADE OF THE CD40/CD154 PATHWAY ENHANCES T-CELLDEPLETED ALLOGENEIC BONE MARROW ENGRAFTMENT UNDER NONMYELOABLATIVE AND IRRADIATION-FREE CONDITIONING THERAPY
Author(s) -
Yisheng Pan,
Bin Luo,
H. Sozen,
Hannes Kalscheuer,
Bruce R. Blazar,
David E.R. Sutherland,
Bernhard J. Hering,
Zhixin Guo
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000069602.30162.a1
Subject(s) - cd154 , bone marrow , immunology , fludarabine , medicine , transplantation , cd40 , total body irradiation , cyclophosphamide , cancer research , biology , cytotoxic t cell , in vitro , chemotherapy , biochemistry
T-cell-depleted bone marrow transplantation (TDBMT) can prevent graft-versus-host disease (GvHD). However, depleting T cells from allogeneic bone marrow often results in failure of bone marrow engraftment under irradiation conditioning. It is not know whether donor T cells are essential for bone marrow engraftment and whether blocking the CD40/CD154 pathway promotes allogeneic TDBM engraftment under nonmyeloablative and irradiation-free fludarabine phosphate and cyclophosphamide conditioning therapy.