Open AccessEndothelin-receptor blockade mitigates the adverse effect of preretrieval warm ischemia on posttransplantation renal function in rats1
Author(s) -
Sharon R. Inman,
Wanda K. Plott,
Ray A. Pomilee,
Jodi Antonelli,
Richard M. Lewis
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000063127.02261.e4
Subject(s) - medicine , renal function , antagonist , transplantation , endothelin receptor , ischemia , urology , nephrectomy , kidney , endothelin 1 , blockade , receptor antagonist , kidney transplantation , endocrinology , receptor
Ischemia-reperfusion injury has been established as a nonimmunologic risk factor for the development of chronic graft nephropathy after renal transplantation. This objective of this study was to determine if oral administration of an endothelin-1 receptor (ET-R) antagonist over a 2-month period after renal transplantation would mitigate long-term dysfunction associated with 30 min of preretrieval warm ischemia (pre-WI).