Open AccessHigh diversity of non-human leukocyte antigens in transplant-associated coronary artery disease1
Author(s) -
Ruth L. Bates,
Geoffrey Frampton,
Marlene L. Rose,
John J. Murphy
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000061790.08550.ec
Subject(s) - antigen , human leukocyte antigen , cdna library , complementary dna , antibody , clone (java method) , immunology , coronary artery disease , biology , pathogenesis , transplantation , medicine , gene , genetics
Antibodies to endothelial derived non-human leukocyte antigens (HLA) have been associated with transplant (Tx)-associated coronary artery disease (CAD) after cardiac transplantation; however, few have been identified. The aim of this study was to screen a human coronary artery endothelial cell cDNA library with patient sera to establish the diversity and nature of the target antigens.