Open AccessFTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A
Author(s) -
T Koshiba,
Boudewijn Van Damme,
Omer Rutgeerts,
Mark Waer,
Jacques Pirenne
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000058469.38572.10
Subject(s) - medicine , heart transplantation , transplantation , ciclosporin , intimal hyperplasia , immunology , lymphocyte , regimen , pharmacology , smooth muscle
Chronic rejection remains the leading cause of failure after transplantation (Tx). FTY720, a new immunosuppressant altering lymphocyte trafficking, is effective against acute rejection, but its activity against chronic rejection is not known.