Open AccessFormation of donor-specific human leukocyte antigen antibodies after kidney transplantation: correlation with acute rejection and tapering of immunosuppression
Author(s) -
Barbara J. van der Mast,
Nicole M. van Besouw,
Marian D. Witvliet,
P. de Kuiper,
Peter Smak Gregoor,
Teun van Gelder,
Willem Weimar,
Frans H.J. Claas
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000054840.70526.d0
Subject(s) - immunosuppression , transplantation , medicine , azathioprine , kidney transplantation , antibody , immunology , panel reactive antibody , kidney , gastroenterology , disease
Before kidney transplantation, a serological crossmatch is routinely performed between donor and recipient to prevent hyperacute rejection by donor-specific anti-human leukocyte antigen (HLA) antibodies. After transplantation, the presence of these antibodies is not routinely monitored. We wanted to know whether donor-specific anti-HLA antibodies are detectable during acute rejection (AR), before or after reduction of immunosuppression in kidney transplant recipients who were converted from cyclosporine A (CsA) to the less nephrotoxic azathioprine (AZA) or mycophenolate mofetil (MMF) at 1 year after transplantation.