Formation of donor-specific human leukocyte antigen antibodies after kidney transplantation: correlation with acute rejection and tapering of immunosuppression | Zendy

Barbara J. van der Mast | Zendy; Nicole M. van Besouw | Zendy; Marian D. Witvliet | Zendy; P. de Kuiper | Zendy; Peter Smak Gregoor | Zendy; Teun van Gelder | Zendy; Willem Weimar | Zendy; Frans H.J. Claas | Zendy

Open Access

Formation of donor-specific human leukocyte antigen antibodies after kidney transplantation: correlation with acute rejection and tapering of immunosuppression

Author(s) -

Barbara J. van der Mast,

Nicole M. van Besouw,

Marian D. Witvliet,

P. de Kuiper,

Peter Smak Gregoor,

Teun van Gelder,

Willem Weimar,

Frans H.J. Claas

Publication year - 2003

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/01.tp.0000054840.70526.d0

Subject(s) - immunosuppression , transplantation , medicine , azathioprine , kidney transplantation , antibody , immunology , panel reactive antibody , kidney , gastroenterology , disease

Before kidney transplantation, a serological crossmatch is routinely performed between donor and recipient to prevent hyperacute rejection by donor-specific anti-human leukocyte antigen (HLA) antibodies. After transplantation, the presence of these antibodies is not routinely monitored. We wanted to know whether donor-specific anti-HLA antibodies are detectable during acute rejection (AR), before or after reduction of immunosuppression in kidney transplant recipients who were converted from cyclosporine A (CsA) to the less nephrotoxic azathioprine (AZA) or mycophenolate mofetil (MMF) at 1 year after transplantation.

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